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Assay Detail

CHEMBL5620541

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Binding
Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by fluorescence based analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Phosphodiesterase 7 (CHEMBL2111411)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Advances in the development of phosphodiesterase 7 inhibitors.
Huang JX, Zhu BL, Xu JP, Zhou ZZ.
Eur J Med Chem (2023) 250 : 115194 -115194
PubMed 36796299 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.69 8.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5625053 1 8.26
CHEMBL5630856 1 8.21
CHEMBL5624926 1 7.70
CHEMBL183965 1 7.26
CHEMBL5624721 1 7.13
CHEMBL5625128 1 7.00
CHEMBL5629944 1 6.89
CHEMBL1236215 1 6.29
CHEMBL1927722 1 6.26
CHEMBL3545918 1 5.96
CHEMBL5630770 1 5.94
CHEMBL184334 1 5.82
CHEMBL5631032 1 5.80
CHEMBL503420 1 5.10
CHEMBL5625119 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5625053 IC50 = 5.5 nM 8.26
CHEMBL5630856 IC50 = 6.1 nM 8.21
CHEMBL5624926 IC50 = 20.0 nM 7.70
CHEMBL183965 IC50 = 55.0 nM 7.26
CHEMBL5624721 IC50 = 74.0 nM 7.13
CHEMBL5625128 IC50 = 100.0 nM 7.00
CHEMBL5629944 IC50 = 130.0 nM 6.89
CHEMBL1236215 IC50 = 510.0 nM 6.29
CHEMBL1927722 IC50 = 550.0 nM 6.26
CHEMBL3545918 IC50 = 1110.0 nM 5.96
CHEMBL5630770 IC50 = 1150.0 nM 5.94
CHEMBL184334 IC50 = 1500.0 nM 5.82
CHEMBL5631032 IC50 = 1590.0 nM 5.80
CHEMBL503420 IC50 = 8000.0 nM 5.10
CHEMBL5625119 IC50 < 10.0 nM -