Compound Detail
CHEMBL503420
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Basic Information
| ChEMBL ID | CHEMBL503420 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MQZXGMYANOJYIY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
198.2
MW (Da)
0.66
ALogP
2
HBA
2
HBD
78.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 7 CHEMBL2111411 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 7 | IC50 | = | 8000.0 | nM | 5.1 | Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by f... | 36796299 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18082290 | 10.1016/j.ejmech.2007.10.027 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
| 18082290 | 10.1016/j.ejmech.2007.10.027 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | 1 |
| 18082290 | 10.1016/j.ejmech.2007.10.027 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 36796299 | 10.1016/j.ejmech.2023.115194 | Phosphodiesterase 7 | 1 |
Data from ChEMBL 36 via Core Engine