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Assay Detail

CHEMBL5621452

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-SB-222200 from recombinant human NK3R expressed in CHO-K1 cells membrane incubated for 2 hrs by microbeta scintillation counting method
ChEMBL ↗
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuromedin-K receptor (CHEMBL4429) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of piperazinotriazoles. Discovery of a potent and orally bioavailable neurokinin-3 receptor inhibitor.
Ye L, Yang Y, Li C, Zhang J, Wang W, Ma M, Xu H, Zhang W, Zou F, Hu Z, Wang H, Tian J.
Eur J Med Chem (2023) 257 : 115486 -115486
PubMed 37247507 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 6.68 8.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5631018 — — 1 8.18
CHEMBL3422018 — — 1 7.74
CHEMBL5625091 — — 1 7.33
CHEMBL5630439 — — 1 7.20
CHEMBL5625030 — — 1 7.15
CHEMBL5630574 — — 1 7.12
CHEMBL5630592 — — 1 7.11
CHEMBL5624619 — — 1 7.00
CHEMBL5624800 — — 1 6.98
CHEMBL5624825 — — 1 6.98
CHEMBL3608680 FEZOLINETANT 4.0 1 6.96
CHEMBL5630243 — — 1 6.90
CHEMBL5630897 — — 1 6.89
CHEMBL5631195 — — 1 6.86
CHEMBL5624666 — — 1 6.83
CHEMBL5630463 — — 1 6.80
CHEMBL5624693 — — 1 6.78
CHEMBL5630784 — — 1 6.77
CHEMBL5631093 — — 1 6.72
CHEMBL5630303 — — 1 6.63
CHEMBL5624614 — — 1 6.60
CHEMBL5630966 — — 1 6.54
CHEMBL5631119 — — 1 6.31
CHEMBL5631189 — — 1 6.23
CHEMBL5630096 — — 1 6.20
CHEMBL5624928 — — 1 6.03
CHEMBL5624987 — — 1 5.59
CHEMBL5630156 — — 1 5.49
CHEMBL5631127 — — 1 5.27
CHEMBL5629992 — — 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5631018 — IC50 = 6.6 nM 8.18
CHEMBL3422018 — IC50 = 18.26 nM 7.74
CHEMBL5625091 — IC50 = 46.4 nM 7.33
CHEMBL5630439 — IC50 = 63.34 nM 7.20
CHEMBL5625030 — IC50 = 70.85 nM 7.15
CHEMBL5630574 — IC50 = 76.24 nM 7.12
CHEMBL5630592 — IC50 = 78.12 nM 7.11
CHEMBL5624619 — IC50 = 101.13 nM 7.00
CHEMBL5624800 — IC50 = 104.49 nM 6.98
CHEMBL5624825 — IC50 = 105.48 nM 6.98
CHEMBL3608680 FEZOLINETANT IC50 = 109.78 nM 6.96
CHEMBL5630243 — IC50 = 126.38 nM 6.90
CHEMBL5630897 — IC50 = 127.92 nM 6.89
CHEMBL5631195 — IC50 = 139.49 nM 6.86
CHEMBL5624666 — IC50 = 149.62 nM 6.83
CHEMBL5630463 — IC50 = 159.18 nM 6.80
CHEMBL5624693 — IC50 = 166.22 nM 6.78
CHEMBL5630784 — IC50 = 171.11 nM 6.77
CHEMBL5631093 — IC50 = 188.57 nM 6.72
CHEMBL5630303 — IC50 = 236.53 nM 6.63
CHEMBL5624614 — IC50 = 248.78 nM 6.60
CHEMBL5630966 — IC50 = 286.56 nM 6.54
CHEMBL5631119 — IC50 = 494.83 nM 6.31
CHEMBL5631189 — IC50 = 594.15 nM 6.23
CHEMBL5630096 — IC50 = 638.85 nM 6.20
CHEMBL5624928 — IC50 = 923.98 nM 6.03
CHEMBL5624987 — IC50 = 2578.81 nM 5.59
CHEMBL5630156 — IC50 = 3269.47 nM 5.49
CHEMBL5631127 — IC50 = 5405.08 nM 5.27
CHEMBL5629992 — IC50 = 5750.19 nM 5.24
CHEMBL5624882 — IC50 > 10000.0 nM -
CHEMBL5630542 — IC50 - — -
CHEMBL5624456 — IC50 - — -
CHEMBL5630079 — IC50 > 10000.0 nM -
CHEMBL5630528 — IC50 > 10000.0 nM -
CHEMBL5624770 — IC50 > 10000.0 nM -
CHEMBL5630076 — IC50 > 10000.0 nM -
CHEMBL5624894 — IC50 > 10000.0 nM -
CHEMBL5630935 — IC50 > 10000.0 nM -
CHEMBL5630142 — IC50 - — -
CHEMBL5630470 — IC50 - — -
CHEMBL5624892 — IC50 > 10000.0 nM -
CHEMBL5630830 — IC50 > 10000.0 nM -