Assay Detail
Binding
CHEMBL5622104
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Inhibition of CDK7/cyclin H (unknown origin) by ADP-Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 7/ cyclin H (CHEMBL2111288) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Orally bioavailable styryl derivative of rohitukine-N-oxide inhibits CDK9/T1 and the growth of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.76 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630982 | — | — | 1 | 6.27 |
| CHEMBL4079206 | — | — | 1 | 6.15 |
| CHEMBL5629920 | — | — | 1 | 5.84 |
| CHEMBL5630065 | — | — | 1 | 5.79 |
| CHEMBL5629976 | — | — | 1 | 5.29 |
| CHEMBL5630202 | — | — | 1 | 5.19 |
| CHEMBL5630007 | — | — | 1 | - |
| CHEMBL5630828 | — | — | 1 | - |
| CHEMBL5624602 | — | — | 1 | - |
| CHEMBL5630659 | — | — | 1 | - |
| CHEMBL5624888 | — | — | 1 | - |
| CHEMBL5630758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630982 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4079206 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5629920 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5630065 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5629976 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL5630202 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL5630007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630828 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5624602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630659 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5624888 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630758 | — | IC50 | > | 10000.0 | nM | - |