Assay Detail
ADMET
CHEMBL5622152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP1A2 assessed as fluorescence of resorufin
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4'-trifluoromethylchalcones as novel, potent and selective hCYP1B1 inhibitors without concomitant AhR activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.25 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 8.25 |
| CHEMBL571956 | — | — | 1 | - |
| CHEMBL5631027 | — | — | 1 | - |
| CHEMBL5624509 | — | — | 1 | - |
| CHEMBL5624485 | — | — | 1 | - |
| CHEMBL5631062 | — | — | 1 | - |
| CHEMBL5630778 | — | — | 1 | - |
| CHEMBL5630516 | — | — | 1 | - |
| CHEMBL5631026 | — | — | 1 | - |
| CHEMBL5414115 | — | — | 1 | - |
| CHEMBL5630137 | — | — | 1 | - |
| CHEMBL5630901 | — | — | 1 | - |
| CHEMBL5625150 | — | — | 1 | - |
| CHEMBL5631046 | — | — | 1 | - |
| CHEMBL5624595 | — | — | 1 | - |
| CHEMBL5630143 | — | — | 1 | - |
| CHEMBL5630146 | — | — | 1 | - |
| CHEMBL5624463 | — | — | 1 | - |
| CHEMBL5624912 | — | — | 1 | - |
| CHEMBL58557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 5.57 | nM | 8.25 |
| CHEMBL571956 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5631027 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5624509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5624485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5631062 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630778 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630516 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5631026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5414115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630137 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630901 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5625150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5631046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5624595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630143 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5630146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5624463 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5624912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58557 | — | IC50 | > | 100000.0 | nM | - |