Assay Detail
Binding
CHEMBL5622976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PTP1B (unknown origin) using p-NPP as substrate incubated for 30 mins by absorbance based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl)thiazolidine-2,4-dione as a potential multi-target antidiabetic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.97 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630676 | — | — | 1 | 7.38 |
| CHEMBL5624847 | — | — | 1 | 6.93 |
| CHEMBL5624535 | — | — | 1 | 6.89 |
| CHEMBL5631021 | — | — | 1 | 6.86 |
| CHEMBL5624476 | — | — | 1 | 6.77 |
| CHEMBL5630566 | — | — | 1 | 6.75 |
| CHEMBL5630180 | — | — | 1 | 6.71 |
| CHEMBL5631075 | — | — | 1 | 6.70 |
| CHEMBL5624515 | — | — | 1 | 6.54 |
| CHEMBL5624539 | — | — | 1 | 6.45 |
| CHEMBL5624654 | — | — | 1 | 5.99 |
| CHEMBL5624938 | — | — | 1 | 5.90 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.60 |
| CHEMBL5630880 | — | — | 1 | 5.36 |
| CHEMBL5624477 | — | — | 1 | 5.24 |
| CHEMBL5630820 | — | — | 1 | 5.13 |
| CHEMBL5630679 | — | — | 1 | 5.10 |
| CHEMBL5630847 | — | — | 1 | 5.03 |
| CHEMBL5630282 | — | — | 1 | 5.02 |
| CHEMBL5629890 | — | — | 1 | 4.84 |
| CHEMBL5630400 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630676 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5624847 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5624535 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL5631021 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL5624476 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL5630566 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL5630180 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5631075 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5624515 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL5624539 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL5624654 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5624938 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL5630880 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL5624477 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL5630820 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL5630679 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL5630847 | — | IC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL5630282 | — | IC50 | = | 9490.0 | nM | 5.02 |
| CHEMBL5629890 | — | IC50 | = | 14510.0 | nM | 4.84 |
| CHEMBL5630400 | — | IC50 | = | 58060.0 | nM | 4.24 |