Assay Detail
Binding
CHEMBL5622977
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Inhibition of alpha-amylase (unknown origin) using starch as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by absorbance based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl)thiazolidine-2,4-dione as a potential multi-target antidiabetic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.40 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5624535 | — | — | 1 | 6.72 |
| CHEMBL5624476 | — | — | 1 | 6.70 |
| CHEMBL5630676 | — | — | 1 | 6.62 |
| CHEMBL5624847 | — | — | 1 | 6.61 |
| CHEMBL5631075 | — | — | 1 | 6.54 |
| CHEMBL5630566 | — | — | 1 | 6.50 |
| CHEMBL5624515 | — | — | 1 | 6.43 |
| CHEMBL5631021 | — | — | 1 | 6.40 |
| CHEMBL5630180 | — | — | 1 | 6.05 |
| CHEMBL5624539 | — | — | 1 | 6.02 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 4.99 |
| CHEMBL5624654 | — | — | 1 | 4.74 |
| CHEMBL5624938 | — | — | 1 | 4.70 |
| CHEMBL5630880 | — | — | 1 | 4.55 |
| CHEMBL5630847 | — | — | 1 | 4.53 |
| CHEMBL5629890 | — | — | 1 | 4.45 |
| CHEMBL5630679 | — | — | 1 | 4.29 |
| CHEMBL5630282 | — | — | 1 | 4.25 |
| CHEMBL5630820 | — | — | 1 | 4.24 |
| CHEMBL5630400 | — | — | 1 | 4.05 |
| CHEMBL5624477 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5624535 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5624476 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5630676 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL5624847 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5631075 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL5630566 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL5624515 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL5631021 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL5630180 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5624539 | — | IC50 | = | 957.0 | nM | 6.02 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL5624654 | — | IC50 | = | 18410.0 | nM | 4.74 |
| CHEMBL5624938 | — | IC50 | = | 20140.0 | nM | 4.70 |
| CHEMBL5630880 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5630847 | — | IC50 | = | 29440.0 | nM | 4.53 |
| CHEMBL5629890 | — | IC50 | = | 35170.0 | nM | 4.45 |
| CHEMBL5630679 | — | IC50 | = | 51250.0 | nM | 4.29 |
| CHEMBL5630282 | — | IC50 | = | 55670.0 | nM | 4.25 |
| CHEMBL5630820 | — | IC50 | = | 58170.0 | nM | 4.24 |
| CHEMBL5630400 | — | IC50 | = | 89710.0 | nM | 4.05 |
| CHEMBL5624477 | — | IC50 | = | 94080.0 | nM | 4.03 |