Assay Detail
Binding
CHEMBL5623087
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Inhibition of Mycobacterium tuberculosis Uracil-DNA glycosylase using 5'-FAM-CUUUUUGAGCTTTTGCTCAAAAAG-3'-BHQ-1 as substrate measured every 2 mins for 40 mins by fluorescence based analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 2.54 | 3.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1403860 | — | — | 1 | 3.03 |
| CHEMBL566 | URACIL | 3.0 | 1 | 2.69 |
| CHEMBL1561505 | — | — | 1 | 2.55 |
| CHEMBL1232805 | — | — | 1 | 2.53 |
| CHEMBL421646 | BENZOYLENUREA | — | 1 | 2.31 |
| CHEMBL574699 | BARBITURIC ACID | — | 1 | 2.14 |
| CHEMBL5630218 | — | — | 1 | - |
| CHEMBL85398 | THIAZOLIDINEDIONE | 3.0 | 1 | - |
| CHEMBL5624510 | — | — | 1 | - |
| CHEMBL566269 | — | — | 1 | - |
| CHEMBL404480 | — | — | 1 | - |
| CHEMBL5624743 | — | — | 1 | - |
| CHEMBL5630767 | — | — | 1 | - |
| CHEMBL1234101 | LUMICHROME | — | 1 | - |
| CHEMBL1213478 | — | — | 1 | - |
| CHEMBL1235017 | OROTIC ACID | 2.0 | 1 | - |
| CHEMBL792 | URIC ACID | 2.0 | 1 | - |
| CHEMBL5630296 | — | — | 1 | - |
| CHEMBL5624715 | — | — | 1 | - |
| CHEMBL5630838 | — | — | 1 | - |
| CHEMBL5630637 | — | — | 1 | - |
| CHEMBL5630147 | — | — | 1 | - |
| CHEMBL5625081 | — | — | 1 | - |
| CHEMBL5624753 | — | — | 1 | - |
| CHEMBL5624821 | — | — | 1 | - |
| CHEMBL5631172 | — | — | 1 | - |
| CHEMBL5629963 | — | — | 1 | - |
| CHEMBL5629955 | — | — | 1 | - |
| CHEMBL5630600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1403860 | — | IC50 | = | 930000.0 | nM | 3.03 |
| CHEMBL566 | URACIL | IC50 | = | 2050000.0 | nM | 2.69 |
| CHEMBL1561505 | — | IC50 | = | 2800000.0 | nM | 2.55 |
| CHEMBL1232805 | — | IC50 | = | 2930000.0 | nM | 2.53 |
| CHEMBL421646 | BENZOYLENUREA | IC50 | = | 4930000.0 | nM | 2.31 |
| CHEMBL574699 | BARBITURIC ACID | IC50 | = | 7290000.0 | nM | 2.14 |
| CHEMBL5630218 | — | IC50 | = | 5550000.0 | nM | - |
| CHEMBL85398 | THIAZOLIDINEDIONE | IC50 | = | 17300000.0 | nM | - |
| CHEMBL5624510 | — | IC50 | = | 330000.0 | nM | - |
| CHEMBL566269 | — | IC50 | - | — | - | |
| CHEMBL404480 | — | IC50 | - | — | - | |
| CHEMBL5624743 | — | IC50 | - | — | - | |
| CHEMBL5630767 | — | IC50 | = | 6510000.0 | nM | - |
| CHEMBL1234101 | LUMICHROME | IC50 | - | — | - | |
| CHEMBL1213478 | — | IC50 | = | 15920000.0 | nM | - |
| CHEMBL1235017 | OROTIC ACID | IC50 | = | 14200000.0 | nM | - |
| CHEMBL792 | URIC ACID | IC50 | = | 16400000.0 | nM | - |
| CHEMBL5630296 | — | IC50 | = | 10400000.0 | nM | - |
| CHEMBL5624715 | — | IC50 | - | — | - | |
| CHEMBL5630838 | — | IC50 | = | 4200000.0 | nM | - |
| CHEMBL5630637 | — | IC50 | = | 990000.0 | nM | - |
| CHEMBL5630147 | — | IC50 | - | — | - | |
| CHEMBL5625081 | — | IC50 | - | — | - | |
| CHEMBL5624753 | — | IC50 | - | — | - | |
| CHEMBL5624821 | — | IC50 | - | — | - | |
| CHEMBL5631172 | — | IC50 | = | 1060000.0 | nM | - |
| CHEMBL5629963 | — | IC50 | - | — | - | |
| CHEMBL5629955 | — | IC50 | = | 1100000.0 | nM | - |
| CHEMBL5630600 | — | IC50 | - | — | - |