Compound Detail
CHEMBL574699
BARBITURIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL574699 |
| Name | BARBITURIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNYOPLTXPVRDBG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
128.1
MW (Da)
-1.26
ALogP
3
HBA
2
HBD
75.3
PSA (Ų)
0.40
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 3.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 3.0 | 2.57 | 1000000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1000000.0 | nM | 3.0 | Inhibition of Mycobacterium tuberculosis Uracil-DNA glycosylase using 5' 32P end... | 37399710 |
| Unchecked | IC50 | = | 7290000.0 | nM | 2.14 | Inhibition of Mycobacterium tuberculosis Uracil-DNA glycosylase using 5'-FAM-CUU... | 37399710 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-007-9072-1 | Rattus norvegicus | 13 |
| 19552984 | 10.1016/j.ejmech.2009.05.023 | Tyrosinase | 2 |
| 533876 | 10.1021/jm00197a005 | No relevant target | 2 |
| 37399710 | 10.1016/j.ejmech.2023.115604 | Unchecked | 2 |
| 24857777 | 10.1016/j.bmc.2014.04.060 | Tyrosinase | 1 |
| 30565923 | 10.1021/acs.jmedchem.8b01153 | No relevant target | 1 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | Glutaminyl-peptide cyclotransferase | 1 |
Data from ChEMBL 36 via Core Engine