Assay Detail
Functional
CHEMBL5623901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.40 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630358 | — | — | 1 | 9.00 |
| CHEMBL5625076 | — | — | 1 | 9.00 |
| CHEMBL5630522 | — | — | 1 | 8.70 |
| CHEMBL5630288 | — | — | 1 | 8.70 |
| CHEMBL5630586 | — | — | 1 | 8.70 |
| CHEMBL5625083 | — | — | 1 | 8.52 |
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 8.15 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630358 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5625076 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5630522 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5630288 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5630586 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5625083 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3828009 | LY-2874455 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 396.0 | nM | 6.40 |