Assay Detail
Functional
CHEMBL5623904
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Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.38 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630586 | — | — | 1 | 7.42 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630586 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 46.0 | nM | 7.34 |