Assay Detail
Functional
CHEMBL5625283
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Antiproliferative activity against human HT-1080 cells harboring IDH1 R132H mutant measured after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5633478 | — | — | 1 | 9.00 |
| CHEMBL3989958 | IVOSIDENIB | 4.0 | 1 | 8.10 |
| CHEMBL5631386 | — | — | 1 | 8.03 |
| CHEMBL5632259 | — | — | 1 | 7.93 |
| CHEMBL5631626 | — | — | 1 | 7.16 |
| CHEMBL4571722 | — | — | 1 | 6.68 |
| CHEMBL5632034 | — | — | 1 | 6.37 |
| CHEMBL5632655 | — | — | 1 | 5.92 |
| CHEMBL5633668 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5633478 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3989958 | IVOSIDENIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5631386 | — | IC50 | = | 9.39 | nM | 8.03 |
| CHEMBL5632259 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5631626 | — | IC50 | = | 69.6 | nM | 7.16 |
| CHEMBL4571722 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5632034 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL5632655 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5633668 | — | IC50 | = | 2080.0 | nM | 5.68 |