Assay Detail
Binding
CHEMBL5625288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wildtype IDH2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP], mitochondrial (CHEMBL3991501) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.79 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279047 | VORASIDENIB | 4.0 | 1 | 6.43 |
| CHEMBL3989958 | IVOSIDENIB | 4.0 | 1 | 5.14 |
| CHEMBL4651002 | SAFUSIDENIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279047 | VORASIDENIB | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL3989958 | IVOSIDENIB | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4651002 | SAFUSIDENIB | IC50 | > | 10000.0 | nM | - |