Assay Detail
Binding
CHEMBL5625339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal IDH1 R140Q mutant (unknown origin) (40 to 452 residues) expressed in Escherichia coli BL21 (DE3) cells in presence of alpha-KG and NADPH by fluorescence based biochemical assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP], mitochondrial (CHEMBL3991501) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.05 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989908 | ENASIDENIB | 4.0 | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989908 | ENASIDENIB | IC50 | = | 9.0 | nM | 8.05 |