Assay Detail
Binding
CHEMBL5625417
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Inhibition of human NHE-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological activity and mechanism of pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.65 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465179 | — | — | 1 | 10.80 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 9.72 |
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | — | 1 | 8.43 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | - |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465179 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 0.004 | nM | - |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 0.03 | nM | - |