Assay Detail
Binding
CHEMBL5625560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to TRAP1 (unknown origin) assessed as dissociation constant incubated for 24 hrs by fluorescence polarization assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat shock protein 75 kDa, mitochondrial (CHEMBL1075132) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 6.38 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5633903 | — | — | 1 | 7.40 |
| CHEMBL5633816 | — | — | 1 | 7.40 |
| CHEMBL5633571 | — | — | 1 | 7.10 |
| CHEMBL5633012 | — | — | 1 | 7.05 |
| CHEMBL5632075 | — | — | 1 | 7.05 |
| CHEMBL5631806 | — | — | 1 | 6.80 |
| CHEMBL5633174 | — | — | 1 | 6.64 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 6.62 |
| CHEMBL5631336 | — | — | 1 | 6.46 |
| CHEMBL5633431 | — | — | 1 | 6.44 |
| CHEMBL5633987 | — | — | 1 | 6.42 |
| CHEMBL3260480 | — | — | 1 | 6.38 |
| CHEMBL5631777 | — | — | 1 | 6.38 |
| CHEMBL5632244 | — | — | 1 | 6.33 |
| CHEMBL5633752 | — | — | 1 | 6.33 |
| CHEMBL5631620 | — | — | 1 | 6.31 |
| CHEMBL5631997 | — | — | 1 | 6.26 |
| CHEMBL5631343 | — | — | 1 | 6.19 |
| CHEMBL5631613 | — | — | 1 | 6.07 |
| CHEMBL5632194 | — | — | 1 | 6.05 |
| CHEMBL5631423 | — | — | 1 | 6.03 |
| CHEMBL5631707 | — | — | 1 | 6.02 |
| CHEMBL5629930 | — | — | 1 | 5.61 |
| CHEMBL5633082 | — | — | 1 | 5.60 |
| CHEMBL5631756 | — | — | 1 | 5.58 |
| CHEMBL5633971 | — | — | 1 | 5.39 |
| CHEMBL5633893 | — | — | 1 | - |
| CHEMBL5632487 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5633903 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5633816 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5633571 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL5633012 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL5632075 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL5631806 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL5633174 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL200102 | PU-H71 | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL5631336 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL5633431 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL5633987 | — | Kd | = | 380.0 | nM | 6.42 |
| CHEMBL3260480 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL5631777 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL5632244 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL5633752 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL5631620 | — | Kd | = | 490.0 | nM | 6.31 |
| CHEMBL5631997 | — | Kd | = | 550.0 | nM | 6.26 |
| CHEMBL5631343 | — | Kd | = | 650.0 | nM | 6.19 |
| CHEMBL5631613 | — | Kd | = | 860.0 | nM | 6.07 |
| CHEMBL5632194 | — | Kd | = | 890.0 | nM | 6.05 |
| CHEMBL5631423 | — | Kd | = | 930.0 | nM | 6.03 |
| CHEMBL5631707 | — | Kd | = | 960.0 | nM | 6.02 |
| CHEMBL5629930 | — | Kd | = | 2430.0 | nM | 5.61 |
| CHEMBL5633082 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL5631756 | — | Kd | = | 2630.0 | nM | 5.58 |
| CHEMBL5633971 | — | Kd | = | 4040.0 | nM | 5.39 |
| CHEMBL5633893 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5632487 | — | Kd | > | 100000.0 | nM | - |