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Assay Detail

CHEMBL5625564

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Binding
Binding affinity to TRAP1 (unknown origin) assessed as dissociation constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Heat shock protein 75 kDa, mitochondrial (CHEMBL1075132)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Merfeld T, Peng S, Keegan BM, Crowley VM, Brackett CM, Gutierrez A, McCann NR, Reynolds TS, Rhodes MC, Byrd KM, Deng J, Matts RL, Blagg BSJ.
Eur J Med Chem (2023) 258 : 115531 -115531
PubMed 37307624 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.97 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5631777 1 6.36
CHEMBL5631756 1 5.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5631777 Kd = 440.0 nM 6.36
CHEMBL5631756 Kd = 2620.0 nM 5.58