Assay Detail
Binding
CHEMBL5626084
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Inhibition of HDAC4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Are inhibitors of histone deacetylase 8 (HDAC8) effective in hematological cancers especially acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 9.00 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.70 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.19 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | > | 10000.0 | nM | - |