Assay Detail
Binding
CHEMBL5626131
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Inhibition of VEGFR-3 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.18 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303214 | FRUQUINTINIB | 4.0 | 1 | 7.46 |
| CHEMBL5631845 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303214 | FRUQUINTINIB | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5631845 | — | IC50 | = | 125.0 | nM | 6.90 |