Assay Detail
Binding
CHEMBL5626978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.68 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.60 |
| CHEMBL5631356 | — | — | 1 | 7.04 |
| CHEMBL5633239 | — | — | 1 | 6.88 |
| CHEMBL5633979 | — | — | 1 | 6.33 |
| CHEMBL5629932 | — | — | 1 | 6.21 |
| CHEMBL5633087 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5631356 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5633239 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5633979 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5629932 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL5633087 | — | IC50 | = | 927.0 | nM | 6.03 |