Assay Detail
Binding
CHEMBL5627005
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Inhibition of AChE (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.84 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165327 | — | — | 1 | 9.44 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.66 |
| CHEMBL3910142 | — | — | 1 | 7.54 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.11 |
| CHEMBL4581664 | — | — | 1 | 5.14 |
| CHEMBL3410478 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165327 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3910142 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL807 | MEMANTINE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4581664 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL3410478 | — | IC50 | = | 7310.0 | nM | 5.14 |