Assay Detail
Functional
CHEMBL5627606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 F227L/V106A mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.47 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.67 |
| CHEMBL104245 | — | — | 1 | 7.42 |
| CHEMBL5633326 | — | — | 1 | 7.17 |
| CHEMBL5633591 | — | — | 1 | 6.74 |
| CHEMBL5632459 | — | — | 1 | 6.71 |
| CHEMBL5631703 | — | — | 1 | 6.63 |
| CHEMBL5633387 | — | — | 1 | 6.56 |
| CHEMBL5633694 | — | — | 1 | 6.46 |
| CHEMBL5633910 | — | — | 1 | 6.45 |
| CHEMBL5631453 | — | — | 1 | 6.15 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.05 |
| CHEMBL5633430 | — | — | 1 | 5.99 |
| CHEMBL5631612 | — | — | 1 | 5.65 |
| CHEMBL5631702 | — | — | 1 | 4.96 |
| CHEMBL5632723 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 21.4 | nM | 7.67 |
| CHEMBL104245 | — | EC50 | = | 37.8 | nM | 7.42 |
| CHEMBL5633326 | — | EC50 | = | 67.5 | nM | 7.17 |
| CHEMBL5633591 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5632459 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5631703 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL5633387 | — | EC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5633694 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL5633910 | — | EC50 | = | 357.0 | nM | 6.45 |
| CHEMBL5631453 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5633430 | — | EC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL5631612 | — | EC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5631702 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL5632723 | — | EC50 | >= | 17400.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 9513.0 | nM | - |