Assay Detail
Binding
CHEMBL5628124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-mesulergine from human A1AR expressed in Flp-In-T-REx-293 cells assessed as inhibition constant
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Flp-In-T-REx-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationships of 5-HT<sub>2B</sub> and 5-HT<sub>2C</sub> serotonin receptor antagonists: N<sup>6</sup>, C2 and 5'-Modified (N)-methanocarba-adenosine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.77 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5631554 | — | — | 1 | 8.22 |
| CHEMBL5633886 | — | — | 1 | 7.87 |
| CHEMBL5631324 | — | — | 1 | 7.67 |
| CHEMBL4743059 | — | — | 1 | 7.51 |
| CHEMBL5631329 | — | — | 1 | 7.37 |
| CHEMBL5632406 | — | — | 1 | 7.20 |
| CHEMBL5631402 | — | — | 1 | 7.19 |
| CHEMBL5632085 | — | — | 1 | 6.83 |
| CHEMBL5633995 | — | — | 1 | 6.83 |
| CHEMBL5631700 | — | — | 1 | 6.69 |
| CHEMBL2170801 | — | — | 1 | 6.36 |
| CHEMBL5632684 | — | — | 1 | 6.33 |
| CHEMBL5632857 | — | — | 1 | 6.28 |
| CHEMBL5633118 | — | — | 1 | 6.19 |
| CHEMBL5631470 | — | — | 1 | 6.00 |
| CHEMBL5633824 | — | — | 1 | 5.87 |
| CHEMBL5633551 | — | — | 1 | 5.79 |
| CHEMBL5633599 | — | — | 1 | 5.66 |
| CHEMBL5631697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5631554 | — | Ki | = | 5.95 | nM | 8.22 |
| CHEMBL5633886 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL5631324 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL4743059 | — | Ki | = | 30.7 | nM | 7.51 |
| CHEMBL5631329 | — | Ki | = | 42.7 | nM | 7.37 |
| CHEMBL5632406 | — | Ki | = | 63.2 | nM | 7.20 |
| CHEMBL5631402 | — | Ki | = | 63.9 | nM | 7.19 |
| CHEMBL5632085 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL5633995 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL5631700 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL2170801 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL5632684 | — | Ki | = | 466.0 | nM | 6.33 |
| CHEMBL5632857 | — | Ki | = | 529.0 | nM | 6.28 |
| CHEMBL5633118 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL5631470 | — | Ki | = | 998.0 | nM | 6.00 |
| CHEMBL5633824 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL5633551 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL5633599 | — | Ki | = | 2180.0 | nM | 5.66 |
| CHEMBL5631697 | — | Ki | - | — | - |