Assay Detail
Functional
CHEMBL5628154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CAPAN-1 BRCA2-/- cells assessed as inhibition of cell growth incubated for 7 days by CCK-8 assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAPAN-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5633982 | — | — | 1 | 9.00 |
| CHEMBL5631857 | — | — | 1 | 8.60 |
| CHEMBL5633486 | — | — | 1 | 8.47 |
| CHEMBL5632118 | — | — | 1 | 8.14 |
| CHEMBL5632854 | — | — | 1 | 8.14 |
| CHEMBL5631531 | — | — | 1 | 7.86 |
| CHEMBL5632074 | — | — | 1 | 7.67 |
| CHEMBL3903910 | — | — | 1 | 7.53 |
| CHEMBL5633862 | — | — | 1 | 7.26 |
| CHEMBL5632340 | — | — | 1 | 7.22 |
| CHEMBL5632428 | — | — | 1 | 6.66 |
| CHEMBL5633084 | — | — | 1 | 5.84 |
| CHEMBL5631466 | — | — | 1 | - |
| CHEMBL5632868 | — | — | 1 | - |
| CHEMBL3936349 | — | — | 1 | - |
| CHEMBL5632530 | — | — | 1 | - |
| CHEMBL5633542 | — | — | 1 | - |
| CHEMBL5632703 | — | — | 1 | - |
| CHEMBL5632420 | — | — | 1 | - |
| CHEMBL5632796 | — | — | 1 | - |
| CHEMBL5631862 | — | — | 1 | - |
| CHEMBL5633663 | — | — | 1 | - |
| CHEMBL5632742 | — | — | 1 | - |
| CHEMBL5631710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5633982 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5631857 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5633486 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5632118 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5632854 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5631531 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL5632074 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL3903910 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL5633862 | — | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL5632340 | — | IC50 | = | 60.7 | nM | 7.22 |
| CHEMBL5632428 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL5633084 | — | IC50 | = | 1428.0 | nM | 5.84 |
| CHEMBL5631466 | — | IC50 | - | — | - | |
| CHEMBL5632868 | — | IC50 | - | — | - | |
| CHEMBL3936349 | — | IC50 | - | — | - | |
| CHEMBL5632530 | — | IC50 | - | — | - | |
| CHEMBL5633542 | — | IC50 | - | — | - | |
| CHEMBL5632703 | — | IC50 | - | — | - | |
| CHEMBL5632420 | — | IC50 | - | — | - | |
| CHEMBL5632796 | — | IC50 | - | — | - | |
| CHEMBL5631862 | — | IC50 | - | — | - | |
| CHEMBL5633663 | — | IC50 | - | — | - | |
| CHEMBL5632742 | — | IC50 | - | — | - | |
| CHEMBL5631710 | — | IC50 | < | 0.3 | nM | - |