Compound Detail
CHEMBL5633862
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CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(CO[Si](C)(C)C(C)(C)C)n21
Basic Information
| ChEMBL ID | CHEMBL5633862 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTXLQCQRMSYCBP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
562.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CAPAN-1 CHEMBL614536 | IC50 | 7.26 | 7.26 | 54.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CAPAN-1 | IC50 | = | 54.7 | nM | 7.26 | Antiproliferative activity against human CAPAN-1 BRCA2-/- cells assessed as inhi... | 37567056 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37567056 | 10.1016/j.ejmech.2023.115709 | Poly [ADP-ribose] polymerase 1 | 1 |
| 37567056 | 10.1016/j.ejmech.2023.115709 | MDA-MB-436 | 1 |
| 37567056 | 10.1016/j.ejmech.2023.115709 | CAPAN-1 | 1 |
Data from ChEMBL 36 via Core Engine