Assay Detail
Binding
CHEMBL5628523
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Inhibition of recombinant HDAC4 (unknown origin) using trifluoroacetyl lysine as substrate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.53 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3110004 | — | — | 1 | 7.89 |
| CHEMBL5632170 | — | — | 1 | 7.70 |
| CHEMBL5631614 | — | — | 1 | 7.62 |
| CHEMBL5631448 | — | — | 1 | 7.25 |
| CHEMBL5631817 | — | — | 1 | 7.17 |
| CHEMBL5633219 | — | — | 1 | 7.01 |
| CHEMBL5633941 | — | — | 1 | 6.24 |
| CHEMBL5631908 | — | — | 1 | 5.96 |
| CHEMBL5629961 | — | — | 1 | 5.85 |
| CHEMBL5631370 | — | — | 1 | 5.11 |
| CHEMBL5633237 | — | — | 1 | 4.04 |
| CHEMBL5632247 | — | — | 1 | - |
| CHEMBL5633420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3110004 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5632170 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5631614 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5631448 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5631817 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5633219 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5633941 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5631908 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5629961 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5631370 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5633237 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL5632247 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5633420 | — | IC50 | > | 100000.0 | nM | - |