Assay Detail
Binding
CHEMBL5628670
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Inhibition of KAT6A (unknown origin) by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456585 | WM-1119 | — | 1 | 8.70 |
| CHEMBL4455897 | — | — | 1 | 8.10 |
| CHEMBL4470091 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456585 | WM-1119 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4455897 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4470091 | — | IC50 | = | 490.0 | nM | 6.31 |