Assay Detail
Binding
CHEMBL5629494
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Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX kinomescan assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.91 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5633661 | — | — | 1 | 6.62 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.36 |
| CHEMBL5633878 | — | — | 1 | 6.33 |
| CHEMBL5632112 | — | — | 1 | 5.82 |
| CHEMBL5181237 | — | — | 1 | 5.32 |
| CHEMBL5200160 | — | — | 1 | 5.01 |
| CHEMBL5632436 | — | — | 1 | - |
| CHEMBL202721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5633661 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL388978 | STAUROSPORINE | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL5633878 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL5632112 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL5181237 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL5200160 | — | Kd | = | 9800.0 | nM | 5.01 |
| CHEMBL5632436 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL202721 | — | Kd | - | — | - |