Assay Detail
Binding
CHEMBL5629495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R mutant phosphorylation (unknown origin) preincubated for 60 mins in the presence of ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181237 | — | — | 1 | 8.52 |
| CHEMBL5632436 | — | — | 1 | 7.16 |
| CHEMBL5632112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181237 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5632436 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5632112 | — | IC50 | > | 30000.0 | nM | - |