Assay Detail
Binding
CHEMBL5629633
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Inhibition of SARS-CoV-2 3CL protease using Dabcyl-KTSAVLQSGFRKME-Edans as a substrate preincubated for 30 mins followed by substrate addition and measured after for 4 hrs by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Exploring 2-methyl-substituted vitamin K<sub>3</sub> derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.57 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269468 | — | — | 1 | 6.02 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.43 |
| CHEMBL531383 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269468 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL590 | MENADIONE | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL531383 | — | IC50 | = | 5350.0 | nM | 5.27 |