Assay Detail
Binding
CHEMBL5629664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAE (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NEDD8-activating enzyme E1 regulatory subunit (CHEMBL2016431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel benzothiazole derivatives as inhibitors of NEDDylation pathway to inhibit the progression of gastric cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.24 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 8.40 |
| CHEMBL5633567 | — | — | 1 | 8.40 |
| CHEMBL5632724 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5633567 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5632724 | — | IC50 | = | 12000.0 | nM | 4.92 |