Assay Detail
Binding
CHEMBL5629719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of WRN (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (CHEMBL2146312) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1968672 | — | — | 1 | 6.64 |
| CHEMBL1353989 | — | — | 1 | 5.64 |
| CHEMBL1399711 | — | — | 1 | 4.89 |
| CHEMBL1374426 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1968672 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1353989 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1399711 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1374426 | — | IC50 | = | 20000.0 | nM | 4.70 |