Assay Detail
Binding
CHEMBL5629720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human WRN unwinding activity by immunosorbent-based helicase unwinding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (CHEMBL2146312) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.86 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091250 | INDIGOTINDISULFONATE | 4.0 | 1 | 6.70 |
| CHEMBL1367248 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091250 | INDIGOTINDISULFONATE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1367248 | — | IC50 | = | 9800.0 | nM | 5.01 |