Assay Detail
Binding
CHEMBL5629722
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Inhibition of BLM (unknown origin) ATPase activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.20 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1374426 | — | — | 1 | 5.80 |
| CHEMBL1091250 | INDIGOTINDISULFONATE | 4.0 | 1 | 5.48 |
| CHEMBL1968672 | — | — | 1 | 4.95 |
| CHEMBL1367248 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1374426 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1091250 | INDIGOTINDISULFONATE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1968672 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1367248 | — | IC50 | = | 26300.0 | nM | 4.58 |