Assay Detail
Binding
CHEMBL5629798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human FKBP51 FK1 domain expressed in Escherichia coli BL21 DE3 Gold assessed as dissociation constant incubated for 30 mins by competitive fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP5 (CHEMBL2052031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.79 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5634031 | — | — | 1 | 8.17 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.07 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5634031 | — | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL413 | SIROLIMUS | Kd | = | 8.5 | nM | 8.07 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | Kd | = | 75.93 | nM | 7.12 |