Assay Detail
Binding
CHEMBL5634334
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Binding affinity to human DNA polymerase gamma assessed as dissociation constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.02 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | — | 1 | 5.96 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.89 |
| CHEMBL341421 | EMTRICITABINE 5'-TRIPHOSPHATE | -1.0 | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL341421 | EMTRICITABINE 5'-TRIPHOSPHATE | Kd | = | 63000.0 | nM | 4.20 |