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Assay Detail

CHEMBL5634337

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Functional
Antiviral activity against HIV-1 IIIB infected in human H9 cells
12
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type H9
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.
Han S, Lu Y.
Eur J Med Chem (2023) 258 : 115586 -115586
PubMed 37393791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 6.89 7.52
IC90 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222559 TIPRANAVIR 4.0 2 7.52
CHEMBL5639410 2 7.40
CHEMBL5641569 2 6.96
CHEMBL5647064 1 6.85
CHEMBL5639643 2 6.31
CHEMBL5646928 1 6.30
CHEMBL5646997 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222559 TIPRANAVIR IC50 = 30.0 nM 7.52
CHEMBL5639410 IC50 = 40.0 nM 7.40
CHEMBL5641569 IC50 = 110.0 nM 6.96
CHEMBL5647064 IC50 = 140.0 nM 6.85
CHEMBL5639643 IC50 = 490.0 nM 6.31
CHEMBL5646928 IC50 = 500.0 nM 6.30
CHEMBL5646997 IC50 > 1000.0 nM -
CHEMBL222559 TIPRANAVIR IC90 = 100.0 nM -
CHEMBL5639410 IC90 = 260.0 nM -
CHEMBL5641569 IC90 = 890.0 nM -
CHEMBL5646997 IC90 > 1000.0 nM -
CHEMBL5639643 IC90 = 1000.0 nM -