Assay Detail
Functional
CHEMBL5634347
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Antiviral activity against VSV-G pseudotyped HIV-1 infected in HEK293T cells assessed as inhibition of early stage viral replication preincubated with cells for 30 mins followed by viral infection for 3 hrs and measured 48 hrs after media replacement with compound by luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 10.26 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594438 | LENACAPAVIR | 4.0 | 1 | 10.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594438 | LENACAPAVIR | IC50 | = | 0.055 | nM | 10.26 |