Assay Detail
Binding
CHEMBL5634586
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Binding affinity to mushroom Tyrosinase using L-DOPA as substrate assessed as inhibition constant by Michaelis-Menten analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Catechol-mimicking transition-state analogues as non-oxidizable inhibitors of tyrosinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.86 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | — | 1 | 7.16 |
| CHEMBL48310 | HINOKITIOL | — | 1 | 7.05 |
| CHEMBL3978212 | — | — | 1 | 6.46 |
| CHEMBL5647001 | — | — | 1 | 6.25 |
| CHEMBL3907670 | — | — | 1 | 5.99 |
| CHEMBL5434151 | — | — | 1 | 5.92 |
| CHEMBL3969839 | — | — | 1 | 5.92 |
| CHEMBL121188 | TROPOLONE | — | 1 | 5.10 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | — | 1 | 5.02 |
| CHEMBL5500014 | — | — | 1 | 4.90 |
| CHEMBL287899 | — | — | 1 | 4.66 |
| CHEMBL81398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL48310 | HINOKITIOL | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3978212 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL5647001 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3907670 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL5434151 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3969839 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL121188 | TROPOLONE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL5500014 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL287899 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL81398 | — | Ki | = | 128000.0 | nM | - |