Assay Detail
Binding
CHEMBL5635409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KIT D816V mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A review: FDA-approved fluorine-containing small molecules from 2015 to 2022.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.55 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204794 | AVAPRITINIB | 4.0 | 1 | 9.57 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204794 | AVAPRITINIB | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 30.0 | nM | 7.52 |