Assay Detail
Binding
CHEMBL5635459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK5/p25 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT<sub>6</sub>R agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.53 | 8.52 |
| Ki | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191336 | — | — | 1 | 8.52 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.26 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.80 |
| CHEMBL1614763 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191336 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1614763 | — | Ki | = | 600.0 | nM | 6.22 |