Compound Detail
CHEMBL1614763
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1614763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQRVBHMYUSGXHL-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
374.8
MW (Da)
4.26
ALogP
7
HBA
2
HBD
111.2
PSA (Ų)
0.39
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.12
Ki 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 5/CDK5 activator 1 CHEMBL1907600 | Ki | 6.22 | 6.22 | 600.0 | 1 |
| Cyclin-dependent kinase 5/CDK5 activator 1 CHEMBL1907600 | IC50 | 6.12 | 5.91 | 750.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 5/CDK5 activator 1 | Ki | = | 600.0 | nM | 6.22 | Inhibition of CDK5/p25 (unknown origin) | 37657272 |
| Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | = | 750.0 | nM | 6.12 | Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKT... | 21353545 |
| Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISA | 21353545 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21353545 | 10.1016/j.bmcl.2011.01.140 | Cyclin-dependent kinase 5/CDK5 activator 1 | 2 |
| 37657272 | 10.1016/j.ejmech.2023.115756 | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
Data from ChEMBL 36 via Core Engine