Assay Detail
Binding
CHEMBL5635746
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Binding affinity to GRP78 (unknown origin) assessed as dissociation constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Endoplasmic reticulum chaperone BiP (CHEMBL1781865) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.91 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414287 | — | — | 1 | 6.96 |
| CHEMBL5639838 | — | — | 1 | 6.17 |
| CHEMBL5415251 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414287 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL5639838 | — | Kd | = | 679.0 | nM | 6.17 |
| CHEMBL5415251 | — | Kd | = | 25000.0 | nM | 4.60 |