Assay Detail
Binding
CHEMBL5635772
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Inhibition of His-tagged human recombinant GRP78 expressed in Escherichia coli BL21 (DE3) cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Endoplasmic reticulum chaperone BiP (CHEMBL1781865) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414287 | — | — | 1 | 6.23 |
| CHEMBL1439833 | — | — | 1 | 5.58 |
| CHEMBL5424525 | — | — | 1 | 5.46 |
| CHEMBL5308000 | — | — | 1 | 5.12 |
| CHEMBL5415522 | — | — | 1 | - |
| CHEMBL5422201 | — | — | 1 | - |
| CHEMBL5395687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414287 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1439833 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5424525 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5308000 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5415522 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5422201 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5395687 | — | IC50 | > | 100000.0 | nM | - |