Assay Detail
Functional
CHEMBL5635774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of spore germination in Clostridium difficile R20291 assessed as inhibition of spore germination measured every minute for 2 hrs by absorbance based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Clostridioides difficile |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis, and inhibition of Clostridioides difficile spore germination by acyclic and bicyclic tertiary amide analogs of cholate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.01 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639112 | — | — | 1 | 6.40 |
| CHEMBL5640011 | — | — | 1 | 6.00 |
| CHEMBL5646812 | — | — | 1 | 5.10 |
| CHEMBL5646541 | — | — | 1 | 4.66 |
| CHEMBL5647272 | — | — | 1 | 4.54 |
| CHEMBL5641813 | — | — | 1 | 4.50 |
| CHEMBL5639841 | — | — | 1 | 4.43 |
| CHEMBL4524597 | — | — | 1 | 4.42 |
| CHEMBL5646480 | — | — | 1 | - |
| CHEMBL5646771 | — | — | 1 | - |
| CHEMBL5641819 | — | — | 1 | - |
| CHEMBL5647600 | — | — | 1 | - |
| CHEMBL5641711 | — | — | 1 | - |
| CHEMBL5639806 | — | — | 1 | - |
| CHEMBL5646564 | — | — | 1 | - |
| CHEMBL4968703 | — | — | 1 | - |
| CHEMBL5647119 | — | — | 1 | - |
| CHEMBL5639181 | — | — | 1 | - |
| CHEMBL5639639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639112 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5640011 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5646812 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5646541 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5647272 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5641813 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5639841 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4524597 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5646480 | — | IC50 | - | — | - | |
| CHEMBL5646771 | — | IC50 | - | — | - | |
| CHEMBL5641819 | — | IC50 | - | — | - | |
| CHEMBL5647600 | — | IC50 | - | — | - | |
| CHEMBL5641711 | — | IC50 | - | — | - | |
| CHEMBL5639806 | — | IC50 | - | — | - | |
| CHEMBL5646564 | — | IC50 | - | — | - | |
| CHEMBL4968703 | — | IC50 | - | — | - | |
| CHEMBL5647119 | — | IC50 | - | — | - | |
| CHEMBL5639181 | — | IC50 | - | — | - | |
| CHEMBL5639639 | — | IC50 | - | — | - |