Assay Detail
Functional
CHEMBL5635974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.13 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.05 |
| CHEMBL5647194 | — | — | 1 | 7.92 |
| CHEMBL5639782 | — | — | 1 | 7.89 |
| CHEMBL5646529 | — | — | 1 | 7.70 |
| CHEMBL5641808 | — | — | 1 | 7.00 |
| CHEMBL5646681 | — | — | 1 | 6.96 |
| CHEMBL5640027 | — | — | 1 | 6.38 |
| CHEMBL5646415 | — | — | 1 | 6.27 |
| CHEMBL5639150 | — | — | 1 | 5.80 |
| CHEMBL5647505 | — | — | 1 | 5.60 |
| CHEMBL5646607 | — | — | 1 | 5.58 |
| CHEMBL5647015 | — | — | 1 | 5.27 |
| CHEMBL5647428 | — | — | 1 | 5.21 |
| CHEMBL5639220 | — | — | 1 | 5.05 |
| CHEMBL5646779 | — | — | 1 | 5.00 |
| CHEMBL5647563 | — | — | 1 | 4.97 |
| CHEMBL5639993 | — | — | 1 | 4.89 |
| CHEMBL5639942 | — | — | 1 | 4.84 |
| CHEMBL5647022 | — | — | 1 | - |
| CHEMBL5646649 | — | — | 1 | - |
| CHEMBL5639345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5647194 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5639782 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5646529 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5641808 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5646681 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5640027 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5646415 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5639150 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5647505 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5646607 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5647015 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL5647428 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5639220 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5646779 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL5647563 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5639993 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5639942 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5647022 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639345 | — | IC50 | > | 100000.0 | nM | - |