Assay Detail
Functional
CHEMBL5635975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.99 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.15 |
| CHEMBL5647194 | — | — | 1 | 7.92 |
| CHEMBL5639782 | — | — | 1 | 7.85 |
| CHEMBL5646529 | — | — | 1 | 7.25 |
| CHEMBL5646681 | — | — | 1 | 7.06 |
| CHEMBL5640027 | — | — | 1 | 6.33 |
| CHEMBL5641808 | — | — | 1 | 6.28 |
| CHEMBL5646415 | — | — | 1 | 6.10 |
| CHEMBL5647505 | — | — | 1 | 6.09 |
| CHEMBL5646607 | — | — | 1 | 5.51 |
| CHEMBL5639150 | — | — | 1 | 5.50 |
| CHEMBL5647428 | — | — | 1 | 5.12 |
| CHEMBL5647015 | — | — | 1 | 5.07 |
| CHEMBL5646779 | — | — | 1 | 4.88 |
| CHEMBL5639993 | — | — | 1 | 4.87 |
| CHEMBL5639220 | — | — | 1 | 4.85 |
| CHEMBL5647563 | — | — | 1 | 4.59 |
| CHEMBL5639345 | — | — | 1 | 4.38 |
| CHEMBL5647022 | — | — | 1 | - |
| CHEMBL5639942 | — | — | 1 | - |
| CHEMBL5646649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5647194 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5639782 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5646529 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5646681 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5640027 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5641808 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5646415 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5647505 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5646607 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5639150 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL5647428 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL5647015 | — | IC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL5646779 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL5639993 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5639220 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL5647563 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL5639345 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL5647022 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639942 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646649 | — | IC50 | > | 100000.0 | nM | - |