Assay Detail
Binding
CHEMBL5635997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human AChE using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition measured for 3 mins by Ellman's method
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.34 | 6.94 |
| T1/2 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5646469 | — | — | 2 | 6.94 |
| CHEMBL5641542 | — | — | 2 | 6.12 |
| CHEMBL2178782 | — | — | 2 | 5.95 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5646469 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5641542 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL2178782 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL807 | MEMANTINE | IC50 | - | — | - | |
| CHEMBL2178782 | — | T1/2 | > | 1.0 | hr | - |
| CHEMBL5646469 | — | T1/2 | > | 1.0 | hr | - |
| CHEMBL5641542 | — | t1/2 | - | — | - |