Assay Detail
Binding
CHEMBL5636348
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Inhibition of human JNK3 in presence of ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.76 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210618 | — | — | 1 | 8.06 |
| CHEMBL5641916 | — | — | 1 | 8.00 |
| CHEMBL5647005 | — | — | 1 | 7.98 |
| CHEMBL5641827 | — | — | 1 | 7.70 |
| CHEMBL7064 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210618 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5641916 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5647005 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL5641827 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL7064 | — | IC50 | = | 90.0 | nM | 7.05 |