Assay Detail
Binding
CHEMBL5636437
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Inhibition of SOS1 (unknown origin) by HTRF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Son of Sevenless Homologue 1 (SOS1): Promising therapeutic treatment for KRAS-mutant cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.03 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639998 | — | — | 1 | 8.96 |
| CHEMBL5209105 | — | — | 1 | 8.41 |
| CHEMBL5184590 | — | — | 1 | 8.08 |
| CHEMBL5647340 | — | — | 1 | 7.68 |
| CHEMBL5274267 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639998 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5209105 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5184590 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL5647340 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5274267 | — | IC50 | = | 95.4 | nM | 7.02 |